Chemical Synthesis of the GHIJK Ring System and Further Experimental Support for the Originally Assigned Structure of Maitotoxin

Abstract

Accepting the proposal: The originally proposed structure of maitotoxin has recently come under scrutiny based on biosynthetic and computational considerations. A newly synthesized ring framework corresponding to the GHIJK ring domain (see structure) of the molecule provided, through 13C NMR spectroscopic comparisons, strong experimental support for the originally proposed structure.