Concepedia

Publication | Open Access

A Noncanonical Flt3ITD/NF-κB Signaling Pathway Represses <i>DAPK1</i> in Acute Myeloid Leukemia

DOIFull Paper Access

37

Citations

48

References

2011

Year

Rajasubramaniam Shanmugam, Padmaja Gade, Annique Wilson-Weekes, Hamid Sayar, Attaya Suvannasankha, Chirayu Goswami, Lang Li, Sushil Kumar Gupta, Angelo A. Cardoso, Tareq Al Baghdadi,
Clinical Cancer Research

Abstract

Flt3ITD promotes a noncanonical pathway via TAK1 and p52NF-κB to suppress DAPK1 in association with HDACs, which explains DAPK1 repression in Flt3ITD(+) AML.

References

YearCitations

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