DIPYRIDAMOLE AND OTHER PHOSPHODIESTERASE INHIBITORS ACT AS ANTITHROMBOTIC AGENTS BY POTENTIATING ENDOGENOUS PROSTACYCLIN

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Acetylation of prostaglandin synthase by aspirin.

G J Roth, N Stanford, Philip W. Majerus · Proceedings of the National Academy of Sciences · 1975 · 1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

Laurence A. Harker, Russell Ross, S. J. Slichter et al. · Journal of Clinical Investigation · 1976 · 939 citations · Full text

Medicine, Pathobiology, Physiology +17

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

Salvador Moncada, E.A. Higgs, John R. Vane · The Lancet · 1977 · 887 citations

Medicine, Hematology, Pharmacology +13

Modulation of human platelet adenylate cyclase by prostacyclin (PGX)

Robert R. Gorman, S Bunting, O.V. Miller · Prostaglandins · 1977 · 655 citations

Medicine, Biochemistry, Pharmacology +10