Targeting polo-like kinase 1 by NMS-P937 in osteosarcoma cell lines inhibits tumor cell growth and partially overcomes drug resistance

Normal Cells, but Not Cancer Cells, Survive Severe Plk1 Depletion

Xiaoqi Liu, Ming Lei, Raymond L. Erikson · Molecular and Cellular Biology · 2006 · 299 citations · Full text

Tumor Biology, Cell Regulation, Rna Interference +15

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

Surojit Sur, Raymond Pagliarini, Fred Bunz et al. · Proceedings of the National Academy of Sciences · 2009 · 296 citations · Full text

Pathology, Cancer Biology, Tumor Biology +16

Molecular characterization of commonly used cell lines for bone tumor research: A trans‐European EuroBoNet effort

Laura Ottaviano, Karl‐Ludwig Schaefer, Melanie Gajewski et al. · Genes Chromosomes and Cancer · 2009 · 173 citations · Full text

Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1®

Robert W. Robey, Suneet Shukla, Elizabeth M. Finley et al. · Biochemical Pharmacology · 2008 · 160 citations · Full text

Drug Resistance Analysis, Biochemistry, Medicine +7

Small Interfering RNA–Mediated Polo-Like Kinase 1 Depletion Preferentially Reduces the Survival of p53-Defective, Oncogenic Transformed Cells and Inhibits Tumor Growth in Animals

Ran Guan, Paul Tapang, Daniel Albert et al. · Cancer Research · 2005 · 146 citations