Chk1 regulates the density of active replication origins during the vertebrate S phase

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

Qinghua Liu, Saritha Guntuku, Xian-Shu Cui et al. · Genes & Development · 2000 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Replicon Clusters Are Stable Units of Chromosome Structure: Evidence That Nuclear Organization Contributes to the Efficient Activation and Propagation of S Phase in Human Cells

Dean A. Jackson, Ana Pombo · The Journal of Cell Biology · 1998 · 852 citations · Full text

Life Sciences, Cell Biology, Genetics +17

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

Claus Storgaard Sørensen, Randi G. Syljuåsen, Jacob Falck et al. · Cancer Cell · 2003 · 556 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Randi G. Syljuåsen, Claus Storgaard Sørensen, Lasse Tengbjerg Hansen et al. · Molecular and Cellular Biology · 2005 · 553 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Aberrant cell cycle checkpoint function and early embryonic death in <i>Chk1</i>^−/− mice

Hiroyuki Takai, Kaoru Tominaga, Noboru Motoyama et al. · Genes & Development · 2000 · 469 citations · Full text

Life Sciences, Cell Biology, Developmental Biology +17