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Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-κB/p300 binding in human synovial fibroblasts

ImmunologyImmune RegulationImmunologic MechanismInnate ImmunityImmune SystemNf-κb/p300 BindingInflammationCell SignalingIl-8 ExpressionMolecular SignalingChronic InflammationLeptin ReceptorImmune FunctionCell BiologyCytokineSignal TransductionImmune Cell DevelopmentMedicineCell Development