Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades using<i>in vivo</i>imaging model

Abstract

Our data indicate that these tissue-selective adhesion molecules and chemokine/receptor pathways act in concert to attract specialized T-cell populations to mediate cutaneous inflammation. The in vivo imaging technique can be applicable to other models of cutaneous diseases to help with better understanding of the pathogenesis and monitoring the therapeutic effects.