Concepedia

Two novel non-viral gene delivery vectors: low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-β-cyclodextrin or (2-hydroxypropyl)-γ-cyclodextrin

Hongliang Huang, Guping Tang, Qingqing Wang, Da Li, Fen-ping Shen, Jun Zhou, Hai Yu

Chemical Communications · 2006 · 76 citations · 7 references

DOI

Concepts

Abstract

Two novel polymers of low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-beta-cyclodextrin or (2-hydroxypropyl)-gamma-cyclodextrin showed lower cytotoxicity and higher transfection efficiency for the delivery of plasmid DNA compared with those of polyethylenimine (PEI, 25 kDa).

References

7

<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

S. Hacein-Bey-Abina, Christof von Kalle, Manfred Schmidt et al. · Science · 2003 · 3.6K citations

, , +17

In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis

Dagmar Fischer, Youxin Li, Barbara Ahlemeyer et al. · Biomaterials · 2003 · 2.3K citations

, , +16

Size matters: Molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle

W.T. Godbey, Kenneth K. Wu, Antonios G. Mikos · Journal of Biomedical Materials Research · 1999 · 822 citations

, , +16

A tragic setback

Erika Check · Nature · 2002 · 289 citations

Cross-linked Small Polyethylenimines: While Still Nontoxic, Deliver DNA Efficiently to Mammalian Cells in Vitro and in Vivo

Mini Thomas, Qing Ge, James Lu et al. · Pharmaceutical Research · 2005 · 236 citations · Full text

, , +16