Minimal cut sets in biochemical reaction networks

Genome-Scale Reconstruction of the <i>Saccharomyces cerevisiae</i> Metabolic Network

Jochen Förster, Iman Famili, Patrick Fu et al. · Genome Research · 2003 · 1.1K citations · Full text

Boolean formalization of genetic control circuits

René Thomas · Journal of Theoretical Biology · 1973 · 951 citations

Logic Synthesis, Engineering, Boolean Function +7

A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks

Stefan Schuster, David A. Fell, Thomas Dandekar · Nature Biotechnology · 2000 · 945 citations

Biology, Metabolic Network, Systems Biology +15

The <i>Escherichia coli</i> MG1655 <i>in silico</i> metabolic genotype: Its definition, characteristics, and capabilities

Jeremy S. Edwards, Bernhard Ø. Palsson · Proceedings of the National Academy of Sciences · 2000 · 873 citations

Engineering, Genetics, Bacteriology +19

Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth

Rafael U. Ibarra, Jeremy S. Edwards, Bernhard Ø. Palsson · Nature · 2002 · 873 citations

Biology, Evolution Strategy, Optimal Growth +4