Concepedia

OLIGONUCLEOTIDES WITH ISOPOLAR PHOSPHONATE INTERNUCLEOTIDE LINKAGE: A NEW PERSPECTIVE FOR ANTISENSE COMPOUNDS?

Dominik Rejman, Radek Liboska, Z. Točík, Ondřej Pačes, Markéta Rinnová, Pavol Koiš, Ivan Rosenberg

Nucleosides Nucleotides & Nucleic Acids · 2001 · 31 citations · 5 references

DOI

Concepts

Abstract

Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.

References

5

UV spectroscopy study on complexes of phosphonate ApA analogs with poly(U): Promising step in prediction of oligonucleotide analog properties?

Martina Pressová, Magdalena Endová, Radek Liboska et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 28 citations

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Geminal hydroxy phosphonate derivatives of nucleosides: A novel class of nucleoside 5′-monophosphate analogues

Šárka Králı́ková, Miloš Buděšı́nský, Milena Masojı́dková et al. · Tetrahedron Letters · 2000 · 24 citations

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Raman spectroscopic study of triplex-like complexes of polyuridylic acid with the isopolar, non-isosteric phosphonate analogues of diadenosine monophosphate

Jaroslav Hanuš, Klára Chmelová, Josef Štěpánek et al. · Journal of Raman Spectroscopy · 1999 · 23 citations · Full text

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2′,3′-O-Phosphonoalkylidene derivatives of ribonucleosides: Synthesis and reactivity

Magdalena Endová, Milena Masojı́dková, Miloš Buděšı́nský et al. · Tetrahedron · 1998 · 21 citations

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Efficient Synthesis of 2′-Deoxynucleoside 3′-C-Phosphonates: Reactivity of Geminal Hydroxyphosphonate Moiety

Šárka Králı́ková, Miloš Buděšı́nský, Milena Masojı́dková et al. · Nucleosides Nucleotides & Nucleic Acids · 2000 · 16 citations

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