Angiotensin converting enzyme inhibitors. 9. Novel [[N-(1-carboxyl-3-phenylpropyl)amino]acyl]glycine derivatives with diuretic activity

Abstract

A series of molecules 1 having sulfonamide diuretic moieties covalently linked to non-sulfhydryl angiotensin-converting enzyme inhibitors (ACEI) were prepared and tested for both activities. IC50 values for ACEI as low as 7 nM were observed. Discernable diuretic activity was seen for several hydrochlorothiazide-based molecules. Effects of the ACEI and diuretic structures on the respective potencies are discussed.