Leptin replacement therapy does not improve the abnormal lipid kinetics of hypoleptinemic patients with HIV-associated lipodystrophy syndrome

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

Margherita Maffei, Jeffrey L. Halaas, Éric Ravussin et al. · Nature Medicine · 1995 · 3.7K citations

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

Carl Montague, I. Sadaf Farooqi, Jonathan P. Whitehead et al. · Nature · 1997 · 2.9K citations · Full text

Medicine, Endocrinology, Pediatrics +11

A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors

Andrew Carr, Katherine Samaras, Samantha Burton et al. · AIDS · 1998 · 2.4K citations

Medicine, Endocrinology, Nutrition +17

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Yasuhiko Minokoshi, Young‐Bum Kim, Odile D. Peroni et al. · Nature · 2002 · 2K citations

Life Sciences, Endocrinology, Physiology +13

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

I. Sadaf Farooqi, Susan A. Jebb, Gill Langmack et al. · New England Journal of Medicine · 1999 · 2K citations · Full text

Medicine, Endocrinology, Pediatrics +17