Concepedia

Critical residues of epitopes recognized by several anti-p53 monoclonal antibodies correspond to key residues of p53 involved in interactions with the mdm2 protein

Jean-Michel Portefaix, Sabine Thébault, Florence Bourgain‐Guglielmetti, Maguy Del Rio, Claude Granier, Jean‐Claude Mani, Isabelle Navarro‐Teulon, M. Nicolas, Thierry Soussi, Bernard Pau

Journal of Immunological Methods · 2000 · 14 citations · 32 references

DOI

Concepts

References

32

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

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Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

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Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support

Ronald Frank · Tetrahedron · 1992 · 1.1K citations

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Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

Julian Gannon, R Greaves, Richard Iggo et al. · The EMBO Journal · 1990 · 983 citations · Full text

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

Jiayuh Lin, Jiandong Chen, Brian Elenbaas et al. · Genes & Development · 1994 · 652 citations · Full text

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