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Discovery of SAR184841, a potent and long-lasting inhibitor of 11β-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D

Olivier Venier, Cécile Pascal, Alain Braun, Claudie Namane, Patrick Mougenot, Olivier Crespin, François Pacquet, Cécile Mougenot, Catherine Monseau, Bénédicte Onofri,

Bioorganic & Medicinal Chemistry Letters · 2013 · 13 citations · 27 references

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A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

Hiroaki Masuzaki, J. Paterson, Hiroshi Shinyama et al. · Science · 2001 · 1.8K citations

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11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

Yuri Kotelevtsev, Megan C. Holmes, Ann N. Burchell et al. · Proceedings of the National Academy of Sciences · 1997 · 855 citations

, , +17

Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity

Eva Rask, Tommy Olsson, Stefan Söderberg et al. · The Journal of Clinical Endocrinology & Metabolism · 2001 · 638 citations

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Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs

Kelly M. Mahar Doan, Joan E. Humphreys, Lindsey O. Webster et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 626 citations

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The 11-β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy

Julio Rosenstock, Salomon Banarer, Vivian Fonseca et al. · Diabetes Care · 2010 · 314 citations · Full text

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