Formation of fluorine-18 labeled diaryl ureas—labeled VEGFR-2/PDGFR dual inhibitors as molecular imaging agents for angiogenesis

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

Johannes Waltenberger, Lena Claesson‐Welsh, Agneta Siegbahn et al. · Journal of Biological Chemistry · 1994 · 1.7K citations · Full text

Immunology, Huve Cells, Cellular Physiology +16

Selected syntheses of ureas through phosgene substitutes

Franca Bigi, Raimondo Maggi, Giovanni Sartori · Green Chemistry · 2000 · 243 citations

Chemical Engineering, Biosynthesis, Dangerous Reagents +15

Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase.

D Wang, Hui Huang, Andrius Kazlauskas et al. · PubMed · 1999 · 190 citations

Endothelial Cells, Immunology, Glioma +17

Discovery of<i>N</i>-(4-(3-Amino-1<i>H</i>-indazol-4-yl)phenyl)-<i>N</i>‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

Yujia Dai, Kresna Hartandi, Zhiqin Ji et al. · Journal of Medicinal Chemistry · 2007 · 180 citations · Full text

Compound 17P, Drug Target, Chemoprevention Strategy +20

Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[<i>d</i>]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor

Jeff B. Smaill, Brian D. Palmer, Gordon W. Rewcastle et al. · Journal of Medicinal Chemistry · 1999 · 178 citations · Full text