Alterations of high‐mannose type <i>N</i>‐glycosylation in human and mouse osteoarthritis cartilage

Abstract

These findings indicate that alterations in high-mannose type N-glycans and N-glycogenes in chondrocytes correlate with the release of MMP-13 and ADAMTS-5 during cartilage degradation. These findings suggest that N-glycans play a crucial role in the initiation and progression of OA.