New approach toward the total synthesis of (+)-aphidicolin by tandem transannular Diels–Alder/aldol strategy

Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α

Susumu Ikegami, Takahiko Taguchi, Mochihiko Ohashi et al. · Nature · 1978 · 921 citations

Life Sciences, Cell Biology, Molecular Biology +12

Simple and selective method for aldehydes (RCHO) .fwdarw. (E)-haloalkenes (RCH:CHX) conversion by means of a haloform-chromous chloride system

Kazuhiko Takai, Koji Nitta, K. UTIMOTO · Journal of the American Chemical Society · 1986 · 748 citations

Natural Sciences, Chemistry, Analytical Chemistry +6

Total synthesis of (+)-A83543A [(+)-lepicidin A]

David A. Evans, W. Cameron Black · Journal of the American Chemical Society · 1993 · 306 citations

Natural Sciences, Chemistry, Analytical Chemistry +6

The transannular Diels–Alder strategy: applications to total synthesis

Éric Marsault, András Toró, Paweł Nowak et al. · Tetrahedron · 2001 · 168 citations

Natural Sciences, Chemical Engineering, Chemistry +7

X-Ray crystallographic determination of the structure of the antibiotic aphidicolin: a tetracyclic diterpenoid containing a new ring system

K. M. Brundret, William Dalziel, Barrie Hesp et al. · Journal of the Chemical Society Chemical Communications · 1972 · 111 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9