Reversal of Hypermethylation and Reactivation of <i>p16INK4a, RARβ</i>, and <i>MGMT</i> Genes by Genistein and Other Isoflavones from Soy

Abstract

These results indicate that genistein and related soy isoflavones reactivate methylation-silenced genes, partially through a direct inhibition of DNA methyltransferase, which may contribute to the chemopreventive activity of dietary isoflavones.