The effect of osteoprotegerin gene modification on wear debris-induced osteolysis in a murine model of knee prosthesis failure

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

W. Scott Simonet, Dave Lacey, Colin R. Dunstan et al. · Cell · 1997 · 5.1K citations · Full text

Medicine, Biochemistry, Molecular Biology +13

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

Hiroshi Takayanagi, Kouetsu Ogasawara, Shigeaki Hida et al. · Nature · 2000 · 1.4K citations

Medicine, Cell Biology, Immunology +12

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

Ji Li, Ildiko Sarosi, Xiaoqiang Yan et al. · Proceedings of the National Academy of Sciences · 2000 · 1.1K citations

Medicine, Cell Biology, Genetics +17

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

Nobuyuki Udagawa, N. Takahashi, Takuhiko Akatsu et al. · Proceedings of the National Academy of Sciences · 1990 · 1K citations

Medicine, Cell Biology, Immunology +14

The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis.

Steven R. Goldring, A L Schiller, Merrilee S. Roelke et al. · Journal of Bone and Joint Surgery · 1983 · 856 citations · Full text

Medicine, Orthopedic Surgery, Surgery +17