Suicide Gene/Prodrug Therapy for Pancreatic Adenocarcinoma by E. Coli Purine Nucleoside Phosphorylase and 6-Methylpurine 2′-deoxyriboside

Abstract

These preliminary results support the therapeutic potential of the MePdR/ePNP system, which induces a highly cytotoxic effect with a potent bystander effect on pancreatic tumors.