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Drastic change in idiotypic but not antigen-binding specificity of an antibody by a single amino-acid substitution

Immunocytochemical TechniqueAllergyImmunologyAntibody ScreeningSingle Amino-acid SubstitutionAutoimmunityAutoantibodiesAntibody EngineeringProtein EngineeringAntigen ProcessingAntigen-binding SpecificityMedicineDrastic Change