Drastic change in idiotypic but not antigen-binding specificity of an antibody by a single amino-acid substitution

THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY

FC Greenwood, WM Hunter, J. Glover · Biochemical Journal · 1963 · 10.2K citations · Full text

Life Sciences, Biochemistry, Endocrinology +11

A gas-liquid solid phase peptide and protein sequenator.

Rodney M. Hewick, Michael W. Hunkapiller, Leroy Hood et al. · Journal of Biological Chemistry · 1981 · 2.2K citations · Full text

Life Sciences, Biochemistry, Biotechnology +17

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

Alfred L.M. Bothwell, Michael Paskind, Michael Reth et al. · Cell · 1981 · 678 citations

Life Sciences, Genetics, Immunology +17

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

D J McKean, Konrad Hüppi, Michael V. Bell et al. · Proceedings of the National Academy of Sciences · 1984 · 549 citations · Full text

Life Sciences, Biology, Immunology +17

Analysis of the repertoire of anti‐NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response

Michael Reth, G J Hämmerling, Klaus Rajewsky · European Journal of Immunology · 1978 · 317 citations

Life Sciences, Immunology, Molecular Biology +17