Disseminated Gonococcal Infection and Eculizumab—A “High Risk” Connection?

Abstract

In Brief A 28-year-old woman who was undergoing treatment with eculizumab for paroxysmal nocturnal hemoglobinuria presented to the hospital with fevers, chills, headache, and a swollen left index finger. Blood cultures returned positive for Neisseria gonorrhoeae. We report the second case of disseminated gonococcal infection associated with the use of eculizumab. Disseminated gonococcal infection has been associated with terminal complement deficiencies. We present a case of disseminated gonococcal infection associated with the use of the monoclonal antibody drug eculizumab.