Metabolism of Prostaglandins in Rat Liver Mitochondria

Abstract

A series of prostaglandins has been incubated with the β‐oxidizing enzyme system of rat liver. All of the compounds tested were oxidized. Prostaglandin E 1 , prostaglandin B 1 , prostaglandin F 1α and prostaglandin F 1β were converted into the corresponding C 18 homologues. Prostaglandin A 1 , 11α,15‐dihydroxy‐9‐ketoprostanoic acid and 11α‐hydroxy‐9,15‐diketoprostanoic acid yielded mixtures of the C 16 and C 18 homologues. Nor‐prostaglandin F 1α and homo‐prostaglandin F 1α were both converted into trinor‐prostaglandin F 1α .