Concepedia

Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway

Zhuo Zhang, Hui Wang, Li Mao, Elizabeth R. Rayburn, Sudhir Agrawal, Ruiwen Zhang

Oncogene · 2005 · 134 citations · 40 references

DOI

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40

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

Stephen N. Jones, Amy E. Roe, Lawrence A. Donehower et al. · Nature · 1995 · 1.3K citations

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Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2

Muyang Li, Christopher Brooks, Foon Wu-Baer et al. · Science · 2003 · 794 citations

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Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

S. Fakharzadeh, Stephen P. Trusko, Donna L. George · The EMBO Journal · 1991 · 709 citations · Full text

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Identification of a cellular transcription factor involved in E1A trans-activation

Imre Kovesdi, Ronald R. Reichel, Joseph R. Nevins · Cell · 1986 · 555 citations

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