Phosphite Synthesis of Oligodeoxyribonucleotides

Abstract

Data in the literature published between 1983 and 1986 on the synthesis of oligodeoxyribonucleotides from nucleoside derivatives of phosphorous acid are reviewed. Attention is mainly focused on the techniques employed for preparing initial monomers for condensation. The individual stages in the solid-phase phosphite method are presented, and the potential of various approaches for achieving this type of synthesis is discussed. In addition, studies on the synthesis of oligonucleotides with the aid of monoesters of phosphorous acid (phosphonate synthesis) are assessed. The bibliography includes 101 references.