Hepatocytes Determine the Hypoxic Microenvironment and Radiosensitivity of Colorectal Cancer Cells Through Production of Nitric Oxide That Targets Mitochondrial Respiration

The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

Jeremy Brown, Amato J. Giaccia · PubMed · 1998 · 1.5K citations

Medicine, Oncology, Pharmacology +16

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin.

Andreas K. Nüssler, Mauricio Di Silvio, Timothy R. Billiar et al. · The Journal of Experimental Medicine · 1992 · 431 citations · Full text

Life Sciences, Biochemistry, Cell Biology +13

Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes

J. Stadler, Timothy R. Billiar, Ronald Curran et al. · American Journal of Physiology-Cell Physiology · 1991 · 400 citations

Life Sciences, Biochemistry, Physiology +17

Investigation of Drug-Induced Mitochondrial Toxicity Using Fluorescence-Based Oxygen-Sensitive Probes

James T. Hynes, Lisa D. Marroquin, V. I. Ogurtsov et al. · Toxicological Sciences · 2006 · 147 citations

Life Sciences, Pharmacology, Toxicology +17

Arsenic Trioxide Treatment Decreases the Oxygen Consumption Rate of Tumor Cells and Radiosensitizes Solid Tumors

Caroline Diepart, Oussama Karroum, Julie Magat et al. · Cancer Research · 2011 · 131 citations · Full text

Medicine, Oncology, Pharmacology +17