Concepedia

Metabolism and Metabolic Effects of Halopurine Nucleosides in Tumor Cells in Culture

L. Lee Bennett, Chao‐Sung Chang, Paula W. Allan, Doris J. Adamson, Lucy M. Rose, R W Brockman, John A. Secrist, Anita T. Shortnacy, John A. Montgomery

Nucleosides and Nucleotides · 1985 · 33 citations · 17 references

DOI

Concepts

Abstract

Abstract Within a series of halo derivatives of adenosine, deoxyadenosine and arabinosyladenine attempts have been made to correlate structure with cytotoxicity, substrate activity for adenosine deaminase and nucleoside kinases, and efficacy of the corresponding nucleotides against target enzymes.

References

17

Purine Nucleosides. VII. Direct Bromination of Adenosine, Deoxyadenosine, Guanosine, and Related Purine Nucleosides

Richard E. Holmes, Roland K. Robins · Journal of the American Chemical Society · 1964 · 138 citations

, , +9

In vitro biological activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine and the biochemical actions of its triphosphate on DNA polymerases and ribonucleotide reductase from HeLa cells.

Wen‐Chi Tseng, David Derse, Ying‐Chih Cheng et al. · Molecular Pharmacology · 1982 · 132 citations

, , +10

Purine Ribonucleoside Kinase Activity and Resistance to Some Analogs of Adenosine

L. Lee Bennett, Hans Peter Schnebli, Margaret H. Vail et al. · Molecular Pharmacology · 1966 · 80 citations

, , +14

Comparison of the actions of 9-beta-D-arabinofuranosyl-2-fluoroadenine and 9-beta-D-arabinofuranosyladenine on target enzymes from mouse tumor cells.

E. Lucile White, Sue C. Shaddix, R W Brockman et al. · PubMed · 1982 · 73 citations

, , +14

Calf intestine adenosine deaminase. Substrate specificity

Lionel N. Simon, Randy J. Bauer, Richard L. Tolman et al. · Biochemistry · 1970 · 66 citations

, , +10