Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

Tsutomu Shimada, Carrie L. Hayes, Hiroshi Yamazaki et al. · PubMed · 1996 · 795 citations

Pharmacy, Biochemistry, Toxicology +17

Blood Cannabinoids. I. Absorption of THC and Formation of 11-OH-THC and THCCOOH During and After Smoking Marijuana*

Marilyn A. Huestis, Jack E. Henningfield, Edward J. Cone · Journal of Analytical Toxicology · 1992 · 521 citations

Pharmacy, Pharmacokinetics, Pharmacology +12

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

Thomas R. Sutter, Yamei Tang, Carrie L. Hayes et al. · Journal of Biological Chemistry · 1994 · 509 citations · Full text

Life Sciences, Genetics, Molecular Biology +9

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

Linda M. Distlerath, P.E.B. Reilly, M V Martin et al. · Journal of Biological Chemistry · 1985 · 318 citations · Full text

Medicine, Biochemistry, Pharmacology +17