Concepedia

Chloroquine Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Lysosomal Bone Morphogenetic Protein Type II Receptor Degradation

Lü Long, Xudong Yang, Mark Southwood, Junyu Lu, Stefan J. Marciniak, Benjamin J. Dunmore, Nicholas W. Morrell

Circulation Research · 2013 · 280 citations · 29 references

DOIFull text

Open access

Abstract

Chloroquine and hydroxychloroquine exert beneficial effects in experimental PAH. The mechanism of action includes inhibition of autophagy pathways and inhibition of lysosomal degradation of BMPR-II.

References

29

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