High-throughput, computer assisted, specific MetID. A revolution for drug discovery

MetaSite:  Understanding Metabolism in Human Cytochromes from the Perspective of the Chemist

Gabriele Cruciani, Emanuele Carosati, Benoît De Boeck et al. · Journal of Medicinal Chemistry · 2005 · 491 citations

Medicine, Medicinal Chemistry, Pharmacology +17

High-resolution mass spectrometry for integrated qualitative and quantitative analysis of pharmaceuticals in biological matrices

Gérard Hopfgartner, David Tonoli, Emmanuel Varesio · Analytical and Bioanalytical Chemistry · 2011 · 162 citations

Pharmacy, Pharmaceutical Analysis, Pharmaceutics +16

Predicting Drug Metabolism:  A Site of Metabolism Prediction Tool Applied to the Cytochrome P450 2C9

Ismael Zamora, Lovisa Afzelius, Gabriele Cruciani · Journal of Medicinal Chemistry · 2003 · 137 citations

Medicine, Medicinal Chemistry, Pharmacology +17

General unknown screening in hair by liquid chromatography–hybrid quadrupole time-of-flight mass spectrometry (LC–QTOF-MS)

Sebastian Broecker, Sieglinde Herre, Fritz Pragst · Forensic Science International · 2011 · 124 citations

Pharmacy, Toxicology, Analytical Chemistry +13

Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time‐of‐flight and LTQ‐Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification <i>in vitro</i> – amitriptyline and verapamil as model compounds

Timo Rousu, Jukka Herttuainen, Ari Tolonen · Rapid Communications in Mass Spectrometry · 2010 · 97 citations · Full text

Life Sciences, Pharmaceutical Analysis, Pharmacology +17