Local Administration of Various Cytostatic Drugs after Subcutaneous Immunization Enhances Delayed‐Type Hypersensitivity Reaction to Sheep Red Blood Cells in Mice

Abstract

Delayed hypersensitivity reaction in mice was enhanced with various anti-cancer drugs administered at the site of antigenic stimulation during 4 days following sensitization. The immunopotentiating effect of the presented local chemotherapy protocol is thought to result from impairment of a regulatory circuit, with activated suppressor T cells (Ts) as target rather than Ts precursors or Ts-inducing antigen-presenting cells.