A case–control study of methylenetetrahydrofolate reductase polymorphisms in cervical carcinogenesis

A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects?

N.M.J. van der Put, F. Gabreëls, E M Stevens et al. · The American Journal of Human Genetics · 1998 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage

Benjamin C. Blount, M. M. Mack, Carol M. Wehr et al. · Proceedings of the National Academy of Sciences · 1997 · 1.4K citations

Life Sciences, Genetics, Molecular Biology +17

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

Jing Ma, Meir J. Stampfer, Edward L. Giovannucci et al. · PubMed · 1997 · 794 citations

Medicine, Genetics, Oncology +16

The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia.

Rowena G. Matthews, Martha Ludwig, Brian Guenther et al. · Nature Structural Biology · 1999 · 419 citations

Life Sciences, Biochemistry, Molecular Biology +16

Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors.

Maria F. Paz, Sonia Avila, Mario F. Fraga et al. · PubMed · 2002 · 247 citations

Medicine, Genetics, Oncology +17