AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells

Akt Stimulates Aerobic Glycolysis in Cancer Cells

Rebecca Elstrom, Daniel E. Bauer, Monica Buzzai et al. · Cancer Research · 2004 · 1.5K citations

Medicine, Cancer Biology, Oncology +17

Positron emission tomography provides molecular imaging of biological processes

Michael E. Phelps · Proceedings of the National Academy of Sciences · 2000 · 1.2K citations

Medicine, Nuclear Medicine, Oncology +17

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

Kathrin Gottlob, Nathan Majewski, Scott Kennedy et al. · Genes & Development · 2001 · 948 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Omid Vafa, Mark Wade, S Kern et al. · Molecular Cell · 2002 · 871 citations · Full text

Medicine, Cancer Biology, Molecular Biology +16

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

Jeffrey C. Rathmell, Casey Fox, David R. Plas et al. · Molecular and Cellular Biology · 2003 · 569 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17