Concepedia

Molecular Strategy to Reduce In Vivo Collagen Barrier Promotes Entry of NCX1 Positive Inducible Pluripotent Stem Cells (iPSCNCX1+) into Ischemic (or Injured) Myocardium

Wei Huang, Bo Dai, Zhili Wen, Ronald W. Millard, Xi-Yong Yu, Kristin Luther, Meifeng Xu, Ting C. Zhao, Huang-Tian Yang, Zhihua Qi,

PLoS ONE · 2013 · 21 citations · 29 references

DOIFull text

Open access

Abstract

Overexpression of miR-29b significantly reduced scar formation after MI and facilitated iPSC(NCX1+) penetration from the cell patch into the infarcted area, resulting in restoration of heart function after MI.

References

29

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

David T. Dudley, Long Pang, Stuart J. Decker et al. · Proceedings of the National Academy of Sciences · 1995 · 2.7K citations · Full text

, , +14

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

Thomas Thum, Carina Gross, Jan Fiedler et al. · Nature · 2008 · 2.3K citations

, , +10

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

Eva van Rooij, Lillian B. Sutherland, Jeffrey E. Thatcher et al. · Proceedings of the National Academy of Sciences · 2008 · 1.8K citations · Full text

, , +16

Induction of pluripotent stem cells from fibroblast cultures

Kazutoshi Takahashi, Keisuke Okita, Masato Nakagawa et al. · Nature Protocols · 2007 · 1.1K citations

, , +8

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

Gilles Pagès, Philippe Lenormand, Gilles L’Allemain et al. · Proceedings of the National Academy of Sciences · 1993 · 998 citations · Full text

, , +19