Concepedia

Metabolism of the Endocrine Disruptor Pesticide-Methoxychlor by Human P450s: Pathways Involving a Novel Catechol Metabolite

Yiding Hu, David Kupfer

Drug Metabolism and Disposition · 2002 · 69 citations · 33 references

DOI

Concepts

References

33

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

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Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

Linda B. Moore, Derek J. Parks, Stacey A. Jones et al. · Journal of Biological Chemistry · 2000 · 810 citations · Full text

, , +17

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

Tatsuya Sueyoshi, Takeshi Kawamoto, Igor N. Zelko et al. · Journal of Biological Chemistry · 1999 · 671 citations · Full text

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The Effects of Perinatal/Juvenile Methoxychlor Exposure on Adult Rat Nervous, Immune, and Reproductive System Function,

Robert E. Chapin · Fundamental and Applied Toxicology · 1997 · 273 citations

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Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation

William H. Bulger, Roseanna M. Muccitelli, David Kupfer · Biochemical Pharmacology · 1978 · 242 citations

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