Parenteral Nutrition Impairs Gut-Associated Lymphoid Tissue and Mucosal Immunity by Reducing Lymphotoxin β Receptor Expression

Abstract

LTbetaR expression is critical for GALT control mechanisms and intact mucosal immunity. PN reduces LTbetaR expression, PP lymphocytes, and intestinal IgA production. Exogenous LTbetaR stimulation reverses PN-induced depression of gut mucosal immunity.