Direct Optical Resolution of Carboxylic Acids by Chiral HPLC on Tris(3,5-dimethylphenylcarbamate)s of Cellulose and Amylose

Abstract

Abstract A variety of racemic carboxylic acids have been for the first time directly resolved by normal-phase, high-performance liquid chromatography using a hexane-2-propanol eluting system containing a small amount (≈1%) of a strong carboxylic acid, like formic acid, trichloroacetic acid, and trifluoroacetic acid.