Improved Cyclodextrin Chiral Phases: A Comparison and Review

Abstract

Abstract Cyclodextrin chiral phases have been shown to be widely applicable for the separation of enantiomers, diastereomers, structural isomers and routine compounds. Two innovations have recently occured in this field. First, the efficiency and selectivity of the β-cyclodextrin column has been improved. Second, compatable TLC plates which produce separations analogous to the columns have been developed. These results are discussed subsequent to a brief review of published work. In addition, the mechanism of separation on cyclodextrin bonded media, solvent effects, temperature effects and structural effects on chiral separations are considered.