Detection of mutations in ectopic factor VIII transcripts from nine haemophilia A patients and the correlation with phenotype

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.3K citations · Full text

Life Sciences, Microbiology, Molecular Biology +10

A comprehensive set of sequence analysis programs for the VAX

John Devereux, Paul Haeberli, Oliver Smithies · Nucleic Acids Research · 1984 · 14.4K citations · Full text

Life Sciences, Bioinformatics, Genetics +8

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

Ulf Gyllensten · Proceedings of the National Academy of Sciences · 1988 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Structure of human factor VIII

Gordon A. Vehar, Bruce A. Keyt, Dan Eaton et al. · Nature · 1984 · 895 citations

Medicine, Hematology, Molecular Biology +12

Inversions disrupting the factor VIII gene are a common cause of severe haemophilia A

Delia Lakich, Haig H. Kazazian, Stylianos E. Antonarakis et al. · Nature Genetics · 1993 · 796 citations · Full text

Medicine, Genetics, Molecular Genetics +11