Concepedia

Factor Viii Alterations

Factor VIII Alterations is a coagulation abnormality characterized by quantitative or qualitative deviations in Factor VIII, a key clotting protein, that impair the intrinsic pathway of hemostasis and predispose individuals to bleeding disorders such as hemophilia A or von Willebrand disease.

2.3K

Publications

114.5K

Citations

8.7K

Authors

1.9K

Institutions

Publications per year

2017–2026

216

Parents

Publications

2.3K

Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector

Mark A. Kay, Catherine S. Manno, Margaret V. Ragni et al. · Nature Genetics · 2000 · 1K citations

, , +14

von Willebrand disease (VWD): evidence‐based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA) <sup>1</sup>

William L. Nichols, MB Hultin, Allison James et al. · Haemophilia · 2008 · 958 citations

, , +17

Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis.

G C White, Frits R. Rosendaal, Louis M. Aledort et al. · PubMed · 2001 · 803 citations

, , +15

Inversions disrupting the factor VIII gene are a common cause of severe haemophilia A

Delia Lakich, Haig H. Kazazian, Stylianos E. Antonarakis et al. · Nature Genetics · 1993 · 796 citations · Full text

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High Plasma Levels of Factor VIII and the Risk of Recurrent Venous Thromboembolism

Paul A. Kyrle, Erich Minar, Mirko Hirschl et al. · New England Journal of Medicine · 2000 · 764 citations · Full text

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1–5 of 2.3K

Authors

8.7K

  1. JO
    Johannes Oldenburg

    University of Bonn, Germany

    38 publications · 2.9K citations

    31

    h-index

  2. PM
    Pier Mannuccio Mannucci

    University of Milan, Italy

    28 publications · 2.7K citations

    24

    h-index

  3. EG
    Edward G. D. Tuddenham

    University College London, United Kingdom

    25 publications · 2.3K citations

    22

    h-index

  4. RS
    R. Schwaab

    University of Bonn, Germany

    25 publications · 1.7K citations

    22

    h-index

  5. SE
    Stylianos E. Antonarakis

    University of Geneva, Switzerland

    26 publications · 2.6K citations

    21

    h-index

1–5 of 8.7K

Institutions

1.9K

  1. University of Milan

    Milan, Italy

    32 h-index

    126 publications

    11.3K citations

  2. Inserm

    Paris, France

    30 h-index

    187 publications

    8.7K citations

  3. Leiden University Medical Center

    Leiden, The Netherlands

    28 h-index

    111 publications

    10.2K citations

  4. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    28 h-index

    126 publications

    8.8K citations

  5. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    Milan, Italy

    28 h-index

    90 publications

    7.4K citations

  6. University College London

    London, United Kingdom

    27 h-index

    128 publications

    6.9K citations

  7. University of Washington

    Seattle, United States

    26 h-index

    104 publications

    5.4K citations

  8. University Medical Center Utrecht

    Utrecht, The Netherlands

    26 h-index

    110 publications

    10.2K citations

1–8 of 1.9K

Venues

  1. Blood

    190 publications · 13.9K citations

    66

    h-index

  2. Thrombosis and Haemostasis

    182 publications · 10K citations

    52

    h-index

  3. British Journal of Haematology

    BJH · 134 publications · 6.9K citations

    46

    h-index

  4. PubMed

    Repository · 182 publications · 7.4K citations

    42

    h-index

  5. Haemophilia

    140 publications · 6.2K citations

    42

    h-index

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