Comparison of three derivatization reagents for the simultaneous determination of highly hydrophilic pyrimidine antitumor agents in human plasma by LC–MS/MS

Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators

Tetsuhiko Shirasaka, Yuji Shimamato, Hideyuki Ohshimo et al. · Anti-Cancer Drugs · 1996 · 824 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats.

Tetsuhiko Shirasaka, K Nakano, T Takechi et al. · PubMed · 1996 · 370 citations

Medicine, Oncology, Pharmacology +9

Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts.

Kunihiko Tatsumi, Masakazu Fukushima, Tetsuhiko Shirasaka et al. · PubMed · 1987 · 261 citations

Life Sciences, Biochemistry, Pharmacology +10

Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor drug.

Keiji Hirata, N Horikoshi, K Aiba et al. · PubMed · 1999 · 227 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Challenge of high polarity and low concentrations in analysis of cytostatics and metabolites in wastewater by hydrophilic interaction chromatography/tandem mass spectrometry

Lubomira Kovalova, Christa S. McArdell, Juliane Hollender · Journal of Chromatography A · 2008 · 116 citations

Natural Sciences, Chemistry, Pharmaceutical Analysis +16