Enantioselective Synthesis of a Highly Preorganised 2′-Deoxy-spiro-nucleoside

Abstract

The synthesis of a novel spiro-nucleotide, in which the C(4′) and the C(5′) of a nucleotide are connected by an additional ethylene bridge, is reported. The γ-torsional angle of the resulting novel nucleotides is in the region of the one observed in natural double stranded DNA.