Concepedia

Nucleotide Synthesis Pathways

Nucleotide Synthesis Pathways is a biochemical framework that specifies the stepwise enzymatic and abiotic processes through which nucleotides are formed from simpler precursor molecules under prebiotic or cellular conditions, distinguishing it from related metabolic pathways by its focus on the de novo generation of nucleotide monomers essential for RNA and DNA assembly in the context of chemical evolution.

1.3K

Publications

79.4K

Citations

4.3K

Authors

1.1K

Institutions

Publications per year

2017–2026

177

Parents

Publications

1.3K

On the Regulation of DNA Replication in Bacteria

F Jacob, Sydney Brenner, François Cuzin · Cold Spring Harbor Symposia on Quantitative Biology · 1963 · 1.4K citations

, , +14

Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

Matthew W. Powner, Béatrice Gerland, John D. Sutherland · Nature · 2009 · 1.4K citations

, , +12

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

Richard Mulligan, Paul Berg · Proceedings of the National Academy of Sciences · 1981 · 1K citations · Full text

, , +14

Expression of a Bacterial Gene in Mammalian Cells

Richard Mulligan, Paul Berg · Science · 1980 · 785 citations

, , +13

Enzymatic Synthesis of Deoxyribonucleic Acid

John Josse, A.D. Kaiser, Arthur Kornberg · Journal of Biological Chemistry · 1961 · 755 citations · Full text

, , +14

1–5 of 1.3K

Authors

4.3K

  1. AK
    Arthur Kornberg

    Stanford University, United States

    25 publications · 6.9K citations

    25

    h-index

  2. HG
    H. G. Khorana

    Massachusetts Institute of Technology, United States

    14 publications · 1K citations

    13

    h-index

  3. JD
    John D. Sutherland

    MRC Laboratory of Molecular Biology, United Kingdom

    13 publications · 1.9K citations

    12

    h-index

  4. JW
    Jack W. Szostak

    Massachusetts General Hospital, United States

    12 publications · 711 citations

    12

    h-index

  5. PR
    Peter Reichard

    Karolinska Institutet, Sweden

    11 publications · 1.7K citations

    11

    h-index

1–5 of 4.3K

Institutions

1.1K

  1. Stanford University

    Stanford, United States

    27 h-index

    86 publications

    25.4K citations

  2. Harvard University

    Cambridge, United States

    27 h-index

    121 publications

    12.6K citations

  3. Massachusetts Institute of Technology

    Cambridge, United States

    25 h-index

    123 publications

    6.7K citations

  4. National Institutes of Health

    Bethesda, United States

    18 h-index

    59 publications

    2.8K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    18 h-index

    64 publications

    3.9K citations

  6. University of Chicago

    Chicago, United States

    18 h-index

    63 publications

    7.2K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    18 h-index

    102 publications

    5.1K citations

  8. University of Wisconsin–Madison

    Madison, United States

    17 h-index

    81 publications

    7.5K citations

1–8 of 1.1K

Venues

  1. Journal of Biological Chemistry

    JBC · 157 publications · 16.7K citations

    65

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  2. Proceedings of the National Academy of Sciences

    PNAS · 52 publications · 4.5K citations

    40

    h-index

  3. Journal of Molecular Biology

    JMB · 39 publications · 2.8K citations

    29

    h-index

  4. Journal of Bacteriology

    JB · 57 publications · 2.4K citations

    28

    h-index

  5. PubMed

    Repository · 49 publications · 2.7K citations

    28

    h-index

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