Critical proinflammatory role of thymic stromal lymphopoietin and its receptor in experimental autoimmune arthritis

Abstract

TSLP and its receptor enhance Th17-driven arthritis and tissue destruction in experimental arthritis. The increased expression of TSLP as well as the increased number of TSLPR-expressing cells in the joints of patients with RA suggest that TSLP and its receptor constitute novel therapeutic targets in RA.