NEW TYPE OF PREFABRICATED FULLY PROTECTED RIBONUCLEOTIDE MONOMER UNITS AS USEFUL SYNTHETIC INTERMEDIATES IN RAPID OLIGORIBONUCLEOTIDE SYNTHESIS

Abstract

Abstract Oligoribonucleotide synthesis has been done by employing newly constructed fully protected ribonucleotide units, S,S-diphenyl 5′-O-dimethoxytrityl-2′-O-tetrahydropyranyl-N-monomethoxytritylnucleoside 3′-phosphorodithioates 7. The units were found to be useful synthetic intermediates for rapid oligoribonucleotide synthesis.