Concepedia

Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells

Andrzej Ptasznik, Yuji Nakata, Anna Kalota, Stephen G. Emerson, Alan M. Gewirtz

Nature Medicine · 2004 · 228 citations · 10 references

DOI

Concepts

References

10

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature · 2001 · 9.4K citations

, , +7

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

Brian Druker, Moshe Talpaz, Debra Resta et al. · New England Journal of Medicine · 2001 · 5.2K citations · Full text

, , +12

A minute chromosome in human chronic granulocytic leukemia

Peter C. Nowell̀ · Medical Entomology and Zoology · 1960 · 2.3K citations

, , +12

BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571

Nicholas J. Donato, Ji Yuan Wu, Jonathan Stapley et al. · Blood · 2002 · 663 citations · Full text

, , +11

Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia

Yiguo Hu, Yuhua Liu, Shawn D. Pelletier et al. · Nature Genetics · 2004 · 404 citations

, , +9