Effects of Loperamide Oxide on Gastrointestinal Transit Time and Anorectal Function in Patients with Chronic Diarrhoea and Faecal Incontinence

Abstract

Loperamide oxide is effective in the treatment of diarrhoea with faecal incontinence; normalization of colon transit time and an increase in the tone of the IAS seem to be the main determinants of efficacy.