Chemistry Letters · 1981 · 53 citations · 5 references
PharmacyBiochemistryChemistryCarbohydrate BiochemistryCarbohydrate ChemistryOrganic ChemistryMonosaccharide ChemistryMonosaccharide StereochemistryMonosaccharide StructureAmination ReactionsCarbohydrate AminationCarbohydrate Stereochemistry DeterminationChromatographic Separation Of SugarsMonosaccharide AnalysisOligosaccharide CharacterizationStereochemistry Of Sugar DerivativesStereoselective Amination
Abstract Acyclic diastereoisomers, 1-deoxy-1-(N-acetyl-α-methylbenzylamino)alditol acetates, are readily obtained by reductive amination of sugars with chiral α-methylbenzylamine in the presence of sodium cyanoborohydride. Ten pairs of enantiomers of common monosaccharides are resolved by an adsorption HPLC on the diastereoisomers.
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