γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

Qinghua Liu, Saritha Guntuku, Xian-Shu Cui et al. · Genes & Development · 2000 · 1.6K citations · Full text

Essential role of <i>BETA2/NeuroD1</i> in development of the vestibular and auditory systems

Min Liu, Fred A. Pereira, Steven D. Price et al. · Genes & Development · 2000 · 626 citations · Full text

Neurotology, Synaptic Signaling, Sensory Systems +25

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

Sonya Zabludoff, Chun Deng, Michael Grondine et al. · Molecular Cancer Therapeutics · 2008 · 407 citations · Full text

Cell Death, Cell Cycle, Cancer Biology +17

G2 checkpoint abrogators as anticancer drugs

Takumi Kawabe · Molecular Cancer Therapeutics · 2004 · 383 citations · Full text

Translating cancer research into targeted therapeutics

Johann S. de Bono, Alan Ashworth · Nature · 2010 · 337 citations

Drug Targeting, Tumor Targeting, Targeted Therapy +7