FK506 is superior to methotrexate in therapeutic effects on advanced stage of rat adjuvant-induced arthritis

A method for measurement of analgesic activity on inflamed tissue.

Lowell O. Randall, Joseph J. Selitto · PubMed · 1957 · 1.6K citations

Inflammation, Health Sciences, Acute Pain +9

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

Bruce N. Cronstein, Dwight Naime, Edward Ostad · Journal of Clinical Investigation · 1993 · 673 citations · Full text

Inflammation, Molecular Pharmacology, Local Adenosine Release +15

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

Michael J. Tocci, D A Matkovich, Kathy Collier et al. · The Journal of Immunology · 1989 · 669 citations

Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation.

S Sawada, Gen Suzuki, Yoshiko Kawase et al. · The Journal of Immunology · 1987 · 417 citations · Full text

Immune Regulation, Immunology, Cyclosporin A +16

Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides.

Lucio Morabito, M. Carmen Montesinos, David Schreibman et al. · Journal of Clinical Investigation · 1998 · 261 citations · Full text

Cell Death, Ecto-5'-nucleotidase-mediated Conversion, Chemical Biology +17